Scientists are learning new ways through which nicotinamide adenine dinucleotide (NAD+), can facilitate the healthy lives and increased lifespans. The levels of NAD+ will substantially decline with age, hence creating a deficiency in energy the ability of the human body to remain fully functional. According to studies, typical humans may only retain half the count of NAD+ they had in youth by the time they are 50 years old. Imagine how this count will look like at the age of 90.
How NAD+ Works to Accelerate or Slow Aging Process
Low NAD+ levels or its deficiency predisposes the body to accelerated aging as well as impeding the body’s ability to benefit fully from resveratrol. Luckily though, restoration of NAD+ cellular count to the recommended amounts does not require rocket science knowledge.
As a major cofactor in the transfer of cell energy, NAD has a crucial function in regulating the aging processes as follows:
NAD+ Can Contribute to Long Telomeres
To begin with, it may be helpful to note that NAD is essential for sirtuin proteins to function properly. The sirtuins are what help in contributing to longer lifespans, as well as maintaining the length of telomeres.
Telomeres are just DNA strands that cap the ends of chromosomes. When cells replicate, the telomeres become shorter. This shortening trend will eventually get to levels where the cell can no longer replicate. Once body cells stop renewing due to lack of end caps to hold chromosomes, it results in increased aging or the death of the those cells.
The more you keep having non-replicating cells, and others dying, the aging process is highly accelerated. Therefore, shortening of telomeres is an indication of cellular aging and can predict shortened lifespans. Research has been going on to find drugs and interventions that can lengthen these strands of DNA, so that lifespan and health span can be extended. To this day, exercising and losing weight have shown tremendous impact on lengthening telomeres.
There are other nutritional supplements such as resveratrol, which can be used to activate sirtuins and help to extend longevity, but emerging study findings show that sirtuins will only work best when they have an adequate supply of NAD+. Being able to increase the length of telomeres using nicotinamide adenine dinucleotide is very useful in slowing aging and increasing lifespan.
NAD Promotes DNA Repair
While DNA is usually protected by the chromosomal cover, it is still extremely susceptible to damage. In most cases, DNA is damaged through broken strands and mutations in vital genes. When this keeps happening, the accumulation of damaged DNA cells can result in faster aging. Eventually, it can also lead to specific diseases that shorten lifespans like a weak immune system and cancer.
When DNA has been damaged, PARP-1 enzyme is activated to cause intracellular DNA repair. For this to take place, PARP-1 will need large amounts of nicotinamide adenine dinucleotide. Therefore, the repair of DNA within cells leads to the depletion of NAD+. This hinders the ability of PARP-1 to repair other damaged DNA proteins. This is why it is important to ensure your NAD+ levels are maintained at the recommended levels.